Sildenafil, available to buy as Generic Sildenafil online from a genuine online drugstore and under innumerable other trade names, is a type of medication used to treat ED and pulmonary arterial hypertension (PAH). Generic Sildenafil is used in the treatment of ED, the inability to get and/or maintain an erection of the male genitals that is adequate for sexual intercourse.
Although sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on U.S. TV. Innumerable sites on the Internet offer Generic Sildenafil for sale after an “online speak station”, often a simple web questionnaire. The “Generic Sildenafil ” name has become so well known that many fake aphrodisiacs now call themselves “herbal Generic Sildenafil ” or are presented as blue tablets imitating the shape and colour of Pfizer’s product. Generic Sildenafil is also informally known as “Vitamin V”, “the Blue Pill”, as well as innumerable other nicknames.
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections.Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil might be unable to create an erection. Other types of medications that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).
Recommendations are given to males with kidney or liver impairments, and males over age 65, start at the lowest possible dosage of Generic Sildenafil (25 mg). Clinical tests have indicated that the type of medication builds up in the plasma of these patients to a concentration that is between three and eight times higher than normal. Caution is also recommended in prescribing the type of medication to individuals with retinitis pigtosa, an unusual genetic eye disorder. Generic Sildenafil might only be taken once per day by anyone.
Men who take medicines with nitrates (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) might never take Generic Sildenafil , as the interaction between the two type of medications could possibly cause a dramatic drop in blood pressure, and possibly be a utilizing factor of a heart attack or stroke. This includes the illegal recreational type of medications such as amyl nitrates.
A number of insurance plans provide coverage or reimbursed for sildenafil provided it is given to treat ED. A 1999 report issued by a health insurance speak touring group indicated that almost half of the males taking Generic Sildenafil at least once weekly have insurance reimbursed for the type of medication. The tablets cost approximately $10 each, and insurers could possibly limit coverage to a specific number of tablets each month.